Thermo Fisher Scientific mGluR1 (extracellular) Polyclonal Antibody, Atto 488

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: 1:20

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
• Ships as lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Glutamate is the main excitatory neurotransmitter in the brain. Initially known to act only on ligand-gated receptor channels (NMDA, AMPA, kainate) responsible for fast excitatory synaptic transmission, it is now recognized to regulate enzymes producing second messengers via G-protein–coupled metabotropic glutamate receptors (mGluRs).
Group-I receptors (mGluR1a, mGluR5) stimulate phospholipase C, increasing phosphoinositide turnover and calcium release.
Group-II (mGluR2, mGluR3) and Group-III receptors inhibit adenylyl cyclase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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