Thermo Fisher Scientific THEM5 Polyclonal Antibody
Rabbit polyclonal antibody against human THEM5 protein. Validated for IHC (Paraffin). Detects endogenous THEM5 involved in mitochondrial fatty acid metabolism. Supplied as liquid, unconjugated form, 0.4 mg/mL concentration, for research use only.
- 카탈로그번호
- PA551205
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length fusion protein of human THEM5 (UniProt ID: Q8N1Q8-1, amino acids 1–247) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636653 |
Product Specific Information
The antibody detects endogenous levels of total THEM5 protein.
Target Information
THEM5 (Thioesterase Superfamily Member 5) is a 247 amino acid protein belonging to the thioesterase superfamily. The gene encoding THEM5 is located on human chromosome 1q21.3, which spans about 260 million base pairs and comprises approximately 8% of the human genome. Chromosome 1 contains around 3,000 genes, many of which are associated with various diseases such as Hutchinson-Gilford progeria, Parkinson’s disease, Gaucher disease, and Usher syndrome.
THEM5 exhibits acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. It plays an important role in mitochondrial fatty acid metabolism and in remodeling of the mitochondrial lipid cardiolipin, which is required for normal mitochondrial function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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