Thermo Fisher Scientific THEM5 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:10–1:50

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total THEM5 protein.

Target Information

THEM5 (Thioesterase Superfamily Member 5) is a 247 amino acid protein belonging to the thioesterase superfamily. The gene encoding THEM5 is located on human chromosome 1q21.3, which spans about 260 million base pairs and comprises approximately 8% of the human genome. Chromosome 1 contains around 3,000 genes, many of which are associated with various diseases such as Hutchinson-Gilford progeria, Parkinson’s disease, Gaucher disease, and Usher syndrome.

THEM5 exhibits acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. It plays an important role in mitochondrial fatty acid metabolism and in remodeling of the mitochondrial lipid cardiolipin, which is required for normal mitochondrial function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.