Thermo Fisher Scientific Lamin A/C Monoclonal Antibody (4E7)
Lamin A/C 단백질 검출용 Thermo Fisher monoclonal antibody (clone 4E7). 인간, 생쥐, 랫드 시료에 반응하며 WB, IHC, ELISA에 적합. 고순도 재조합 LMNA 항원으로 제작되어 높은 특이성과 재현성을 제공.
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Thermo Fisher Scientific Lamin A/C Monoclonal Antibody (4E7)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E7 |
| Immunogen | Purified recombinant fragment of human LMNA expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet Ice |
| RRID | AB_11152687 |
Product Specific Information
MA5-15882 targets LMNA in indirect ELISA, IHC, and WB applications and shows reactivity with human, mouse, and rat samples.
The immunogen is a purified recombinant fragment of human LMNA expressed in E. coli.
MA5-15882 detects LMNA, which has a predicted molecular weight of approximately 74 kDa.
Target Information
Lamins are intermediate filament proteins forming a matrix on the inner surface of the nuclear envelope.
Lamins A and C are alternatively spliced versions of the LMNA gene.
Mutations in LMNA are associated with several disorders including:
- Emery-Dreifuss muscular dystrophy
- Dunnigan-type familial partial lipodystrophy (FPLD)
- Limb-girdle muscular dystrophy (LGMD1B)
- Dilated cardiomyopathy (CMD1A)
- Axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1)
- Mandibuloacral dysplasia (MAD)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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