Thermo Fisher Scientific KVbeta2 (KCNAB2) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 100%

Target Information

Kcnab2 encodes a beta subunit of voltage-gated potassium channels (Kv), which belong to the 6-TM family of potassium channels that also includes the Ca²⁺-activated Slo (7-TM) and SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Kv channels are functionally and structurally complex, regulating processes such as neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.

Four sequence-related potassium channel genes—shaker, shaw, shab, and shal—have been identified in Drosophila, each with human homologs. Kcnab2 acts as an auxiliary beta subunit associating with functional Kv-alpha subunits. Alternative splicing of the Kcnab2 gene results in multiple transcript variants encoding distinct isoforms. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.