Thermo Fisher Scientific KVbeta2 (KCNAB2) Polyclonal Antibody
Thermo Fisher Scientific의 KVbeta2 (KCNAB2) 폴리클로날 항체는 인간 및 마우스 시료에 반응하며 Western blot과 IHC에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 고순도의 Affinity chromatography 정제 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1.0 µg/mL |
| Immunohistochemistry (IHC) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human KCNAB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688342 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 100%
Target Information
Kcnab2 encodes a beta subunit of voltage-gated potassium channels (Kv), which belong to the 6-TM family of potassium channels that also includes the Ca²⁺-activated Slo (7-TM) and SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Kv channels are functionally and structurally complex, regulating processes such as neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes—shaker, shaw, shab, and shal—have been identified in Drosophila, each with human homologs. Kcnab2 acts as an auxiliary beta subunit associating with functional Kv-alpha subunits. Alternative splicing of the Kcnab2 gene results in multiple transcript variants encoding distinct isoforms. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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