Thermo Fisher Scientific KVbeta2 (KCNAB2) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1.0 µg/mL

Immunohistochemistry (IHC)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 100%

Target Information

Kcnab2 is a voltage-gated potassium channel (KV) belonging to the 6-TM family of potassium channels, which also includes the Ca²⁺-activated Slo (7-TM) and SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints.

The diverse functions of potassium channels include:

• Regulating neurotransmitter release
• Controlling heart rate and insulin secretion
• Modulating neuronal excitability
• Managing epithelial electrolyte transport
• Influencing smooth muscle contraction and cell volume

Four sequence-related potassium channel genes — shaker, shaw, shab, and shal — have been identified in Drosophila, each with human homologs.
Kcnab2 is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. Alternative splicing of the Kcnab2 gene results in multiple transcript variants encoding distinct isoforms.

Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.