Thermo Fisher Scientific Phospho-NFkB p105 (Ser907) Polyclonal Antibody
NFkB p105/p50의 Ser907 인산화를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF, IP에 적합. Human 시료 반응성. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NFKB1 (Accession P19838), corresponding to amino acid residues around phosphorylated Ser907 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818298 |
Product Specific Information
This antibody detects endogenous levels of NFκB p105/p50 only when phosphorylated at Serine 907.
Target Information
NF-κB is a nuclear transcription factor activated by various extracellular and intracellular stimuli such as cytokines, UV radiation, stress, injury, and microbial products. It regulates diverse cellular processes including cell growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa subunit of NF-κB, belongs to the Rel protein family. It is synthesized as a p105 precursor containing an N-terminal RHD region with nuclear localization, DNA-binding, and dimerization domains. NFKB1 (p50) forms homodimers or heterodimers with p65 to create functional NF-κB. It is essential for nuclear translocation and DNA binding of NF-κB.
Aberrant NF-κB activity has been implicated in AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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