Thermo Fisher Scientific FOXC1/FOXC2 Polyclonal Antibody
FOXC1/FOXC2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 affinity chromatography로 정제됨. 연구용으로만 사용.
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- PA5101153
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FOXC1 (Accession Q12948), corresponding to amino acid residues N118–L168 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850597 |
Product Specific Information
Antibody detects endogenous levels of total FOXC1/2.
Target Information
The forkhead transcription factor genes FOXC1 (Mf1) and FOXC2 (Mfh1) interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop.
The genes have similar, dose-dependent functions, and compensate for each other in the early development of the heart, blood vessels, and somites.
Both FOXC1 and FOXC2 are expressed in the mesenchyme from which the ocular drainage structures derive, and also interact in kidney and heart development.
Mutations in the FOXC1 gene result in Axenfeld-Rieger malformations of the anterior segment of the eye and lead to an increased susceptibility to glaucoma, including juvenile glaucoma.
Functional regions in FOXC1 are required for nuclear localization and transcriptional regulation. Specifically, two regions in the FOXC1 forkhead domain—one rich in basic amino acid residues and another highly conserved among all FOX proteins—are necessary for nuclear localization of the FOXC1 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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