Thermo Fisher Scientific CD360 (IL-21 Receptor) Monoclonal Antibody (2SX21R), PE, eBioscience

Thermo Fisher Scientific CD360 (IL-21 Receptor) Monoclonal Antibody (2SX21R), PE, eBioscience™

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 5 µL (0.5 µg)/test
• Publications: View 1 publication

Product Specifications

Product Specific Information

This 2SX21R monoclonal antibody reacts with human CD360 (Interleukin-21 Receptor, IL-21R).
IL-21R forms a heterodimeric receptor complex with the common gamma chain to form a functional receptor for IL-21. IL-21 is a class I cytokine of the common gamma chain family and signals through the IL-21R complex to activate the JAK/STAT signaling pathway.

Activation of the JAK/STAT pathway by IL-21 promotes transcription of genes responsive to STAT1 and STAT3. IL-21 is mainly produced by CD4+ T cells and mediates proliferation, differentiation, and effector functions of cells expressing IL-21R such as B cells, T cells, NK cells, dendritic cells, and other myeloid cells.

IL-21 and its receptor are implicated in chronic viral infections, autoimmunity, allergy, organ transplantation, and cancer.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
  • Recommended usage: 5 µL (0.5 µg) per test
  • A test = amount of antibody staining a cell sample in 100 µL final volume
  • Cell number range: 10⁵–10⁸ cells/test

Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

The IL-21 receptor (CD360) is a cytokine receptor belonging to the type I cytokine receptor family.
It forms a heterodimeric complex with the common gamma chain, shared by IL-2 and IL-5 receptors.
This receptor transduces IL-21 growth-promoting signals, regulating proliferation and differentiation of T cells, B cells, and NK cells.
Ligand binding activates JAK1, JAK3, STAT1, and STAT3 pathways.
Knockout studies suggest a role in immunoglobulin production.
Three alternatively spliced transcript variants encoding the same protein have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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