Thermo Fisher Scientific CD360 (IL-21 Receptor) Monoclonal Antibody (2SX21R), PE, eBioscience
인간 IL-21 수용체(CD360)에 특이적인 단클론 항체로, Flow Cytometry용으로 최적화된 PE 형광 표지 제품입니다. JAK/STAT 신호경로 연구 및 면역세포 활성 분석에 적합하며, 고순도 친화 크로마토그래피 정제 및 안정적 저장 조건을 제공합니다.
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Thermo Fisher Scientific CD360 (IL-21 Receptor) Monoclonal Antibody (2SX21R), PE, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.5 µg)/test
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2SX21R |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572610 |
Product Specific Information
This 2SX21R monoclonal antibody reacts with human CD360 (Interleukin-21 Receptor, IL-21R).
IL-21R forms a heterodimeric receptor complex with the common gamma chain to form a functional receptor for IL-21. IL-21 is a class I cytokine of the common gamma chain family and signals through the IL-21R complex to activate the JAK/STAT signaling pathway.
Activation of the JAK/STAT pathway by IL-21 promotes transcription of genes responsive to STAT1 and STAT3. IL-21 is mainly produced by CD4+ T cells and mediates proliferation, differentiation, and effector functions of cells expressing IL-21R such as B cells, T cells, NK cells, dendritic cells, and other myeloid cells.
IL-21 and its receptor are implicated in chronic viral infections, autoimmunity, allergy, organ transplantation, and cancer.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
- Recommended usage: 5 µL (0.5 µg) per test
- A test = amount of antibody staining a cell sample in 100 µL final volume
- Cell number range: 10⁵–10⁸ cells/test
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
The IL-21 receptor (CD360) is a cytokine receptor belonging to the type I cytokine receptor family.
It forms a heterodimeric complex with the common gamma chain, shared by IL-2 and IL-5 receptors.
This receptor transduces IL-21 growth-promoting signals, regulating proliferation and differentiation of T cells, B cells, and NK cells.
Ligand binding activates JAK1, JAK3, STAT1, and STAT3 pathways.
Knockout studies suggest a role in immunoglobulin production.
Three alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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