Thermo Fisher Scientific ATP1A3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove insoluble material.
• Specificity: Na⁺/K⁺ ATPase alpha-3 subunit.

Target Information

The sodium/potassium ATPase is an integral membrane enzyme found in all higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This enzyme is related to other ATPases, including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA).

The sodium/potassium ATPase consists of:

• A large, multipass, transmembrane catalytic alpha subunit
• An associated smaller beta subunit (glycoprotein)

There are three isoforms of the alpha subunit (α1, α2, α3) and two isoforms of the beta subunit (β1, β2), encoded by multigene families.
Expression patterns:

• α1 and β mRNAs: present in all cell types
• α2 and α3 mRNAs: restricted to specific tissues

The α3 subunit is found in neuronal, skeletal, and cardiac muscle, as well as lung and stomach tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.