Thermo Fisher Scientific Huntingtin Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

These polyclonal antibodies are of rabbit origin, developed by immunizing animals with proteins or peptides. The antibody is purified by affinity chromatography from rabbit sera and tested for functionality in relevant research applications.
Developed for Research Use Only and classified as non-hazardous and non-infectious.
This antibody is predicted to react with Monkey, Pig, and Cat.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. The disease is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, translating into a polyglutamine repeat in the protein product.
HD is a mid-life onset autosomal dominant neurodegenerative disease featuring psychiatric disorders, dementia, and involuntary movements (chorea), typically leading to death within 10–20 years.
The huntingtin locus spans 180 kb and consists of 67 exons. It is widely expressed and required for normal development, existing as two alternatively polyadenylated forms with different tissue abundance.
The larger (~13.7 kb) transcript is predominant in adult and fetal brain, while the smaller (~10.3 kb) transcript is more widely expressed. The genetic defect may not eliminate transcription but may alter mRNA or protein function.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.