Thermo Fisher Scientific LNX1 Polyclonal Antibody
LNX1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 최적화되어 있습니다. Human, Mouse, Rat에 반응하며, E3 유비퀴틴 리가아제 연구에 활용됩니다. 고순도 친화 크로마토그래피 정제 및 안정한 보관 용액 구성.
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Applications
Western Blot (WB)
- Tested Dilution: 2–3 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 3–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Multiple peptides against Human LNX1 (aa 200–213, 704–719) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA, 30% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2532783 |
Product Specific Information
This antibody is predicted to react with Monkey, Rat, Mouse, and Goat.
Target Information
Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is also known as PDZRN2 (PDZ domain-containing RING finger 2). Through its RING finger and PDZ domains, Lnx1 forms oligomers and interacts with target proteins such as JAM4 to form multiprotein complexes. Lnx1 functions as an E3 ubiquitin ligase containing NPXY motifs that bind to the phosphotyrosine-binding domain (PTB) on the Numb protein. This interaction mediates ubiquitination of Numb, preventing degradation of the Notch intracellular domain (NICD), thereby positively regulating the Notch signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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