Thermo Fisher Scientific Human/Mouse/Rat Activin A Recombinant Protein, PeproTech
Human, Mouse, Rat 유래 Activin A 재조합 단백질로 TGF-β 슈퍼패밀리 성장인자 연구용. Insect cell 발현, ≥95% 순도, ED50 ≤2.0 ng/ml. 세포 증식 억제 활성 검증됨. 동결건조 형태로 -20°C 보관.
- 카탈로그번호
- 120-14-01M
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to 106 publications (see references)
Miscellaneous PubMed (Misc)
- Refer to 12 publications (see references)
Immunostaining (IS)
- Refer to 1 publication (see references)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human, Mouse, Rat |
| Published species | Amphibian, Bovine, Chicken, Human, Mouse, Pig, Rat |
| Expression System | Insect cells |
| Amino acid sequence | GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS |
| Molecular weight | 26 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% (SDS-PAGE & HPLC) |
| Endotoxin concentration | < 1 EU/µg |
| Activity | Inhibits proliferation of mouse MPC-11 cells. Expected ED50 ≤ 2.0 ng/ml (≥ 5 × 10⁵ units/mg). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
Product Specific Information
- Catalog No. 120-14-1MG is supplied as 2 × 500 µg (120-14-500UG).
- Recombinant Human/Murine/Rat Activin A is a 26 kDa disulfide-linked homodimer of two betaA chains, each containing 116 amino acid residues.
- Shipped at ambient temperature. For detailed storage, handling, and reconstitution information, refer to the lot-specific Certificate of Analysis.
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-β) superfamily. They signal through heteromeric complexes of receptor serine kinases, including type I (I, IB) and type II (II, IIB) receptors. These transmembrane proteins possess extracellular ligand-binding domains, transmembrane regions, and cytoplasmic domains with serine/threonine kinase activity. Type I receptors mediate signaling, while type II receptors are essential for ligand binding and complex formation. Ligand binding induces phosphorylation of type I receptors by type II receptors. Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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