Thermo Fisher Scientific CD42b Monoclonal Antibody (AK2)
인간 CD42b 단백질을 인식하는 마우스 단클론 항체로, Flow Cytometry, ELISA, IP 등에 사용 가능. 단백질 A로 정제된 액상 형태이며, 비접합(Unconjugated) 상태로 제공. 혈소판 활성화 및 응집 관련 연구에 적합.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1:50–1:100
ELISA
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AK2 |
| Immunogen | Human platelet glycoproteins |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538069 |
Additional Formats
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Target Information
CD42b is a platelet activation marker involved in coagulation and platelet aggregation. It interacts with extracellular matrix and adhesion molecules, regulated by VEGF and PDGF. CD42b forms the GPIb-IX-V receptor complex with GPIb beta, GPIX, and GPV, essential for platelet-rich thrombus formation. It binds to von Willebrand factor (VWF) at vascular injury sites and interacts with thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. CD42b is expressed on platelets and megakaryocytes. Mutations or polymorphisms in CD42b are associated with Bernard-Soulier syndromes and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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