Thermo Fisher Scientific ITGA2 Monoclonal Antibody (AK7)

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• PE
• Request custom conjugation

Product Specific Information

Clone AK7 has been reported to work in functional assays.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
A suggested positive control for immunohistochemical applications is tonsil.

Target Information

CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family.
It is a glycoprotein with a molecular weight of 150 kD and complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex.
VLA-2 functions as an extracellular receptor for laminin, collagen, and fibronectin, activating intracellular signaling pathways upon ligand binding.
It plays roles in VEGF-induced angiogenesis, adhesion, and lymphocyte activation.
CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, epithelial cells, and subsets of T and B cells, including CD4⁺ Tr1 cells co-expressing LAG-3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.