
Thermo Fisher Scientific ITGA2 Monoclonal Antibody (AK7)
ITGA2 (CD49b) 단백질을 인식하는 마우스 단클론 항체로, IHC(F), Flow Cytometry, Functional Assay 등에 사용 가능. Human 및 비인간 영장류 반응성. Protein A 정제, PBS 완충액, 0.09% sodium azide 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1:500–1:1,000 | - |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
| ELISA | - | View 1 publication |
| Functional Assay | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AK7 |
| Immunogen | The details of the immunogen for this antibody are not currently available. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538075 |
Additional Formats
Product Specific Information
Clone AK7 has been reported to work in functional assays.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
A suggested positive control for immunohistochemical applications is tonsil.
Target Information
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family.
It is a glycoprotein with a molecular weight of 150 kD and complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex.
VLA-2 functions as an extracellular receptor for laminin, collagen, and fibronectin, activating intracellular signaling pathways upon ligand binding.
It plays roles in VEGF-induced angiogenesis, adhesion, and lymphocyte activation.
CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, epithelial cells, and subsets of T and B cells, including CD4⁺ Tr1 cells co-expressing LAG-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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