Thermo Fisher Scientific P-Selectin Monoclonal Antibody (AK-6), PE

Applications

• Flow Cytometry (Flow)

Tested Dilution: Neat
Publications: N/A

Product Specifications

Additional Formats

• Unconjugated (MA5-16567)
• FITC (MA5-16568)
• Custom conjugation available upon request

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store undiluted at 4°C in the dark.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
• Mouse anti-Human CD62P antibody, clone AK-6 recognizes CD62P (P-selectin), also known as Granule membrane protein 140 (GMP140), Leukocyte-endothelial cell adhesion molecule 3 (LECAM3), or Platelet activation-dependent granule-external membrane protein.

Target Information

P-selectin (CD62P, GMP-140, LECAM3) is a 140 kDa type I transmembrane glycoprotein regulating cell rolling and adhesion. It is stored in Weibel-Palade bodies of endothelial cells and platelet α-granules, rapidly translocated to the cell surface upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP.
P-selectin mediates interactions between activated endothelial cells or platelets with leukocytes, binding sialylated Lewis carbohydrate antigens on neutrophils and monocytes. It plays a key role in inflammation, atherogenesis, thrombosis, and tissue destruction. Clinically, it helps differentiate heparin-induced thrombocytopenia with or without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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