Thermo Fisher Scientific Steroidogenic Factor 1 (SF-1) Recombinant Rabbit Monoclonal Antibody (SF1/8000R)
Recombinant rabbit monoclonal antibody for SF-1 detection in human and rat samples. Suitable for IHC applications with high specificity and reproducibility. Expressed in HEK293 cells and purified via Protein A/G. Stable liquid form for research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SF1/8000R |
| Immunogen | Recombinant fragment (around aa200–400) of human SF-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. SF-1 is essential for fetal development of the hypothalamus, pituitary gland, gonads, and adrenal gland. It promotes transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family.
SF-1 contains two activation function domains (AF1 and AF2) common to nuclear steroid receptors, necessary for interaction with other nuclear receptors, coactivators, and corepressors such as:
- Steroid receptor coactivator-1 (SRC-1)
- Glucocorticoid receptor interacting protein 1 (GRIP1)
- cAMP response element binding protein (CREB) binding protein (CBP)
- Silencing mediator of retinoid acid and thyroid hormone receptor (SMRT)
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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