Thermo Fisher Scientific BDNF Monoclonal Antibody (3R7D0)
BDNF 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. Western blot, IHC, ELISA에 사용 가능. Mouse/Rat 반응성. 고순도 친화크로마토그래피 정제. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| ELISA | 1 µg/mL | View publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3R7D0 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–247 of human BDNF (P23560) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.01 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2848866 |
Product Specific Information
Immunogen sequence:
PMKEANIRGQ GGLAYPGVRT HGTLESVNGP KAGSRGLTSL ADTFEHVIEE LLDEDQKVRP NEENNKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCRGI DKRHWNSQCR TTQSYVRALT MDSKKRIGWR FIRIDTSCVC TLTIKRGR
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. It is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Further processing generates the mature 14 kDa protein, while pro-BDNF remains biologically active and is secreted in synaptic vesicles along with the mature form.
BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several neuron classes. Signaling occurs mainly through the TrkB receptor, though it can also bind to the lower-affinity receptor p75-NTR. BDNF promotes neuronal survival and differentiation, playing a critical role in memory formation and synaptic regulation.
Expression of BDNF is reduced in Alzheimer’s and Huntington’s disease and may influence stress response and mood regulation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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