Thermo Fisher Scientific SPAG5 Monoclonal Antibody (OTI2D6), TrueMAB
SPAG5 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western Blot에 최적화되어 있습니다. 인간 유래 재조합 단백질(aa 1-297)을 면역원으로 사용하였으며, 동결건조 형태로 제공됩니다. 연구용으로 세포 분열 관련 스핀들 형성 및 염색체 안정성 연구에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–297 of human SPAG5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
SPAG5 (Sperm Associated Antigen 5), also known as MAP126, hMAP126, DEEPEST, or Astrin, is a 1,193 amino acid protein highly expressed in testis and at lower levels in liver, placenta, pancreas, colon, and thymus.
It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase, playing a crucial role in spindle formation and mitotic regulation.
SPAG5 contributes to sister chromatid cohesion and separation, maintaining chromosome integrity. It forms homodimers with a long stalk and globular head, creating aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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