Thermo Fisher Scientific Blood Group Antigen H Type 2 (CD173) Monoclonal Antibody (19-OLE)
인체 혈액형 항원 H Type 2(CD173)을 인식하는 mouse monoclonal antibody. IHC(P), IHC(PFA), ICC/IF에 사용 가능. 200 µg/mL 농도의 액상 제품으로 PBS(pH 7.4) 및 0.05% BSA 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 19-OLE |
| Immunogen | Mucinous colonic adenocarcinoma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types.
Individuals with the Bombay phenotype (hh) lack H antigen on red blood cells and therefore do not express A or B antigens. They produce isoantibodies to antigen H as well as to A and B antigens.
If they receive blood from individuals with O blood group, anti-H antibodies bind to the H antigen on donor RBCs, causing complement-mediated lysis. Thus, Bombay phenotype individuals can only receive blood from other hh donors.
Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19, which encodes a fucosyltransferase responsible for producing the H antigen. The H antigen is a carbohydrate sequence mainly linked to protein, with a minor fraction attached to ceramide moiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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