Thermo Fisher Scientific Blood Group Antigen H Type 2 (CD173) Monoclonal Antibody (19-OLE)

Applications

Product Specifications

Target Information

The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types. The Bombay phenotype (hh) lacks antigen H on red blood cells and therefore also lacks A or B antigens, similar to the O blood group. However, unlike the O group, the H antigen is absent, resulting in the production of isoantibodies to antigen H as well as to both A and B antigens.

If individuals with the Bombay phenotype receive blood from someone with O blood group, anti-H antibodies will bind to the H antigen on the donor red blood cells and cause complement-mediated lysis. Therefore, Bombay phenotype individuals can receive blood only from other hh donors, although they can donate as though they were type O.

Some individuals with blood group A1 may also produce anti-H antibodies due to complete conversion of all H antigen to A1 antigen. Production or deficiency of the H antigen is controlled at the H locus on chromosome 19, which contains three exons spanning more than 5 kb of genomic DNA and encodes the fucosyltransferase responsible for producing the H antigen on RBCs. The H antigen is a carbohydrate sequence linked mainly to protein, with a minor fraction attached to ceramide moiety.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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