Thermo Fisher Scientific Blood Group Antigen H Type 2 (CD173) Monoclonal Antibody (A46-B/B10)

Applications and Tested Dilution

Product Specifications

Target Information

The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types. The Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, hence the individuals produce isoantibodies to antigen H as well as to both A and B antigens.

If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on the donor's red blood cells and destroy them by complement-mediated lysis. Therefore, people with the Bombay phenotype can receive blood only from other hh donors, although they can donate as though they were type O.

Some individuals with the blood group A1 may also produce anti-H antibodies due to the complete conversion of all the H antigen to A1 antigen. Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19. The H locus contains three exons spanning more than 5 kb of genomic DNA and encodes the fucosyltransferase that produces the H antigen on RBCs. The H antigen is a carbohydrate sequence linked mainly to protein, with a minor fraction attached to ceramide moiety.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.