Thermo Fisher Scientific PGR Monoclonal Antibody (UMAB136), UltraMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors that mediates the physiological effects of progesterone, crucial for reproductive processes such as pregnancy establishment and maintenance.
PR exists as two isoforms:

• PR-A (94 kDa): lacks 165 amino acids at the N-terminus compared to PR-B.
• PR-B (120 kDa): transcriptionally active form responsible for gene activation related to endometrial maintenance and ovulation inhibition.

In its inactive state, PR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes allow receptor dimerization and binding to progesterone response elements (PRE), activating transcription.
Null mutations in the PGR gene cause reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.