Thermo Fisher Scientific PGR Monoclonal Antibody (UMAB135), UltraMAB
사람 PGR 단백질을 인식하는 Mouse monoclonal 항체로, WB, IHC, ICC, Flow Cytometry에 사용 가능. UMAB135 클론 사용. 액상 형태로 제공되며 PBS, BSA, 글리세롤 완충액에 보관. 번역 개시 부위 차이에 따른 PR-A/B 형태 인식. 연구용 전용 시약.
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Applications 및 Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB135 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–298 of human PGR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to alternative translation initiation sites.
- PR-B: Transcriptionally active form responsible for activating genes for endometrium maintenance, pregnancy, and inhibition of ovulation.
- PR-A: Identical to PR-B except for a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain (ID) that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex including heat shock proteins and immunophilins. Upon progesterone binding, a conformational change allows receptor dimerization and binding to progesterone response elements (PRE), leading to activated transcription.
A null mutation in the PGR gene causes pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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