Thermo Fisher Scientific Phospho-TPL2 (Thr290) Polyclonal Antibody
MAP3K8/COT 단백질의 Thr290 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 시료에 반응. 액상 형태로 제공되며 -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K8 (Accession P41279), corresponding to amino acid residues around phosphorylated Thr290 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816364 |
Product Specific Information
This antibody detects endogenous levels of MAP3K8/COT only when phosphorylated at Threonine 290.
Target Information
MAP3K8 (COT) is a serine/threonine kinase that activates both MAP and JNK kinase pathways, playing a key role in cell cycle regulation.
MAPK signaling cascades include MAPK (ERK), MAPK kinase (MEK), and MAPK kinase kinase (MEKK).
MEKK phosphorylates and activates downstream kinases, leading to MAPK activation.
These kinases are conserved across species, including yeast, Drosophila, and mammals.
MEKK8 activates NF-kappa-B1 via proteasome-mediated proteolysis of NF-kappa-B1/p105.
This cytoplasmic protein is expressed in various normal tissues and tumor-derived cell lines.
The 58 kDa form is activated during the S and G2/M cell cycle phases, while phosphorylation occurs mainly on Ser residues in the longer form and on both Ser and Thr residues in the shorter form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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