Thermo Fisher Scientific CD197 (CCR7) Monoclonal Antibody (3D12), APC, eBioscience
CD197(CCR7) 단일클론 항체(3D12)는 인간 CCR7을 인식하며 APC로 결합된 형태로 제공됩니다. Flow Cytometry에 최적화되어 있으며, T세포 및 수지상세포의 분화·이주 연구에 활용됩니다. 고순도 정제, 안정적 형광 특성, 4°C 보관 권장.
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Thermo Fisher Scientific CD197 (CCR7) Monoclonal Antibody (3D12), APC, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.125 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rhesus monkey |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D12 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1272106 |
Available Formats
- Unconjugated
- APC-eFluor 780
- Biotin
- Brilliant UV 395 / 563 / 661 / 737
- Brilliant Violet 421 / 480 / 711 / 786
- FITC
- NovaFluor Red 685 / 700 / 755
- NovaFluor Yellow 700
- PE / PE-Cyanine5.5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600 / 645 / 780
- Request custom conjugation
Product Specific Information
The 3D12 monoclonal antibody reacts with human CCR7 (CD197), a G-protein-coupled chemokine receptor with seven membrane-spanning domains. CCR7 acts as a receptor for 6Ckine/SLC (CCL19 and CCL21) and plays a key role in T cell migration and dendritic cell maturation.
It distinguishes naive, central, and effector memory T cell populations and is involved in chemotaxis to lymph nodes and immune response regulation.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated for flow cytometry of PBMCs at 5 µL (0.125 µg)/test
- Recommended incubation: ≥45 minutes at 2–8°C for optimal staining
- Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CCR7 belongs to the G protein-coupled receptor family and mediates chemokine signaling. It is expressed in lymphoid tissues, activated B and T lymphocytes, and dendritic cells. CCR7 controls migration of memory T cells to inflamed tissues and promotes dendritic cell maturation.
Its ligands include CCL19 and CCL21, and it is implicated in immune cell trafficking and inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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