Thermo Fisher Scientific CD38 Recombinant Rabbit Monoclonal Antibody (003)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody shows specificity for Human CD38.

Target Information

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of mature lymphocytes, and mediates apoptosis of progenitor cells. It functions as a multi-catalytic ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD+ glycohydrolase) and as a cell surface receptor.

Applications of CD38 antibodies:

• Subtyping lymphomas and leukemias
• Detection of plasma cells (e.g., myeloma identification)
• Marker for activated B and T cells

CD38 also participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.

Associated diseases:
Chronic lymphocytic leukemia, Richter’s Syndrome.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.