Thermo Fisher Scientific MEF2A/MEF2C Recombinant Rabbit Monoclonal Antibody (10I9G9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10I9G9

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 250-473 of human MEF2A+MEF2C (Q06413). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MEF2A/MEF2C,uniProtId:Q02078-1,ncbiNodeId:9606,antigenRange:250-473,antigenLength:507,antigenImageFileName:MA5-42794_MEF2AMEF2C_Q02078-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42794_MEF2AMEF2C_Q02078-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:MEF2A/MEF2C,uniProtId:Q06413-1,ncbiNodeId:9606,antigenRange:250-473,antigenLength:473,antigenImageFileName:MA5-42794_MEF2AMEF2C_Q06413-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42794_MEF2AMEF2C_Q06413-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.7 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911935

Product Specific Information

Positive test controls include: RD, Mouse brain.

Immunogen sequence: NRKPDLRVLI PPGSKNTMPS VSEDVDLLLN QRINNSQSAQ SLATPVVSVA TPTLPGQGMG GYPSAISTTY GTEYSLSSAD LSSLSGFNTA SALHLGSVTG WQQQHLHNMP PSALSQLGAC TSTHLSQSSN LSLPSTQSLN IKSEPVSPPR DRTTTPSRYP QHTRHEAGRS PVDSLSSCSS SYDGSDREDH RNEFHSPIGL TRPSPDERES PSVKRMRLSE GWAT

Target Information

MEF2A is found in many muscle specific-genes mediating cellular functions in skeletal and cardiac muscle. MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.