Thermo Fisher Scientific H3K18me2 Recombinant Rabbit Monoclonal Antibody (RM168)
Histone H3K18me2에 특이적인 재조합 토끼 단클론 항체로 높은 특이성과 감도를 제공. WB, ICC/IF, ELISA, Luminex, Dot blot 등 다양한 응용 가능. HEK293 발현 시스템 기반으로 생산되어 로트 간 일관성 보장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| ELISA | 0.1–0.5 µg/mL |
| Luminex (LUM) | 0.1–0.5 µg/mL |
| Dot blot (DB) | 0.2–1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM168 |
| Immunogen | A dimethyl-peptide corresponding to dimethyl-Histone H3 (Lys18) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2–7.4, with 50% glycerol, 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2661897 |
Product Specific Information
This antibody reacts to Histone H3 monomethylated at Lysine 18 (K18me1).
No cross-reactivity with dimethylated Lysine 18 (K18me2), trimethylated Lysine 18 (K18me3), or other methylations in histone H3.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems.
The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select optimal candidates.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells.
Together with four core histone proteins, it binds to DNA forming the nucleosome structure.
Histones play a central role in transcription regulation, DNA repair, replication, and chromosomal stability.
Post-translational modifications of histones can alter chromatin structure or facilitate transcription factor binding.
The N-terminal tail of histone H3 undergoes methylation, acetylation, and phosphorylation, influencing diverse cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-24677_H3K18me2_P68431-1_Rabbit.svg, MA5-24677_H3K18me2_P68431-1_Rabbit_PDP.jpeg, MA5-24677_H3K18me2_Q71DI3-1_Rabbit.svg, MA5-24677_H3K18me2_Q71DI3-1_Rabbit_PDP.jpeg)
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