Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), APC-Alexa Fluor 750

Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), APC-Alexa Fluor 750

Applications

• Flow Cytometry (Flow): Assay-dependent
  View 5 publications
• Miscellaneous PubMed (Misc): -
  View 1 publication

Product Specifications

Additional Formats Available

• Alexa Fluor 488
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family. It plays a key role in signal transduction, T cell differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with TCR for MHC class I molecules.
The CD8α chain is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers.
Engagement of MHC-I/peptide complexes triggers Lck kinase recruitment, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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