Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), Alexa Fluor 700
CD8α 단백질을 인식하는 Rat 모노클로날 항체로, Alexa Fluor 700 형광 표지로 결합된 제품입니다. Flow Cytometry에 적합하며, 면역세포 표면 CD8 검출용으로 사용됩니다. 연구용으로만 제공되며 4°C에서 보관합니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H10 |
| Immunogen | Con A-stimulated BALB/c splenic T cells |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10375298 |
Additional Formats
- Alexa Fluor 488
- Alexa Fluor 647
- APC
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Custom conjugation available
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family involved in signal transduction and T cell activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, acting as a co-receptor with TCR for MHC-I molecules. CD8α is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers. Interaction with MHC-I/peptide complexes recruits Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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