Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), Alexa Fluor 700

Applications

• Flow Cytometry (Flow)
  Tested Dilution: Assay-dependent

Product Specifications

Additional Formats

• Alexa Fluor 488
• Alexa Fluor 647
• APC
• APC-Alexa Fluor 750
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Custom conjugation available

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family involved in signal transduction and T cell activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, acting as a co-receptor with TCR for MHC-I molecules. CD8α is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers. Interaction with MHC-I/peptide complexes recruits Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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