Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), Alexa Fluor 405
CD8α 단백질을 표적하는 Rat IgG2b 형질의 단클론 항체로, Alexa Fluor 405로 형광 표지됨. Flow Cytometry에 적합하며, 마우스 시료에서 검증됨. 401/422 nm 파장에서 최적의 형광 특성. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), Alexa Fluor 405
Applications
- Flow Cytometry (Flow)
Tested Dilution: Assay-dependent
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H10 |
| Immunogen | Con A-stimulated BALB/c splenic T cells |
| Conjugate | Alexa Fluor™ 405 |
| Excitation / Emission Max | 401 / 422 nm |
| Form | Liquid |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_10372815 |
Additional Formats
- Alexa Fluor 488
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Request custom conjugation
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, essential in signal transduction and T cell activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with TCR for MHC-I molecules. CD8α is crucial for MHC-I binding and is also found on NK cells, monocytes, and dendritic cells as CD8α homodimers. MHC-I/peptide complex ligation recruits Lck, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs play a key role in pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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