Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), Alexa Fluor 647
Thermo Fisher Scientific의 CD8 alpha Monoclonal Antibody (5H10), Alexa Fluor 647은 마우스 CD8 단백질을 표적하는 랫 IgG2b 형질의 단클론 항체입니다. Flow Cytometry에 적합하며 Alexa Fluor 647 형광 표지로 높은 신호 대비를 제공합니다. 연구용으로만 사용됩니다.
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Applications
- Flow Cytometry (Flow): Assay-dependent
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H10 |
| Immunogen | Con A-stimulated BALB/c splenic T cells |
| Conjugate | Alexa Fluor™ 647 |
| Excitation/Emission Max | 650 / 671 nm |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10373094 |
Additional Formats Available
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Request custom conjugation
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a critical role in T cell signal transduction, differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α and CD8β), functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
CD8α is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers. Upon MHC-I/peptide complex ligation, CD8 recruits Lck kinase, promoting lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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