Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), PE-Alexa Fluor 610
Flow Cytometry용 CD8 alpha 단일클론 항체로, PE-Alexa Fluor 610으로 결합되어 높은 형광 감도를 제공합니다. Rat IgG2b 아이소타입이며, 4°C에서 보관합니다. T 세포, NK 세포 등에서 CD8 발현 분석에 적합합니다.
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Applications
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H10 |
| Immunogen | Con A-stimulated BALB/c splenic T cells |
| Conjugate | PE-Alexa Fluor™ 610 |
| Excitation / Emission Max | 567 / 627 nm |
| Form | Liquid |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10372816 |
Additional Formats
- Alexa Fluor 488
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Custom conjugation available upon request
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a key role in signal transduction, T cell differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α and CD8β), functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
CD8α is essential for MHC-I binding and is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells. Engagement of MHC-I/peptide complexes by antigen-presenting cells recruits Lck kinase, leading to lymphokine production, motility, and activation of cytotoxic T lymphocytes (CTLs). Activated CTLs are critical for eliminating pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is promoted by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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