Thermo Fisher Scientific PTMA Polyclonal Antibody

Applications

Tested Dilution

Publications

ELISA (ELISA)

1:500-1:2,000

-

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide based on human thymosin protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2174391

Product Specific Information

PA1-9532 detects Thymosin in human, mouse, pig and rat samples.

PA1-9532 has been successfully used in ELISA procedures.

PA1-9532 immunogen is a synthetic peptide based on human thymosin protein.

Target Information

The thymus gland produces several hormones or hormone-like substances which are derived from a polypeptide precursor containing (in the rat) 113 amino acids and known as prothymosin-alpha. A peptide containing 28 amino acid residues, named thymosin-alpha-1, was originally isolated from calf thymosin fraction 5 and shown to restore various aspects of immune function in several in vitro and invivo test systems. Thymosin-alpha-1 was subsequently isolated from a similar fraction from human thymosin and reported to have the same amino acid sequence as bovine thymosin-alpha-1. In 2003, Jiang et al. identified a pathway that regulates mitochondria-initiated caspase activity. In this pathway, putative human HLA class II-associated protein (PHAP) promoted caspase-9 activation after apoptosome formation, whereas prothymosin-alpha-1 negatively regulated caspase-9 activation by inhibiting apoptosome formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.