Thermo Fisher Scientific POLR3H Polyclonal Antibody
POLR3H 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, 인간·마우스·랫트 시료에 반응. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관, -20°C에서 안정적 유지.
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Thermo Fisher Scientific POLR3H Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human RPC8 (POLR3H, UniProt ID: Q9Y535-1, antigen range: 164–190, length: 204 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635477 |
Product Specific Information
This antibody detects endogenous levels of total RPC8 protein.
Target Information
RPC8 is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates. It is a peripheral component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs.
RPC8 plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It acts as a nuclear and cytosolic DNA sensor involved in the innate immune response and can detect non-self dsDNA, leading to transcription into dsRNA. These non-self RNA polymerase III transcripts, such as Epstein–Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB activation through the RIG-I pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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