Thermo Fisher Scientific POLR3H Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from internal of human RPC8. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:POLR3H,uniProtId:Q9Y535-1,ncbiNodeId:9606,antigenRange:164-190,antigenLength:204,antigenImageFileName:PA5-50024_POLR3H_Q9Y535-1_Rabbit.svg,antigenImageFileNamePDP:PA5-50024_POLR3H_Q9Y535-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2635477

Product Specific Information

The antibody detects endogenous levels of total RPC8 protein.

Target Information

RPC8 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It is acting as nuclear and cytosolic DNA sensor involved in innate immune response. It can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.