Thermo Fisher Scientific POLR3H Polyclonal Antibody

Thermo Fisher Scientific POLR3H Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total RPC8 protein.

Target Information

RPC8 is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates. It is a peripheral component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs.
RPC8 plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It acts as a nuclear and cytosolic DNA sensor involved in the innate immune response and can detect non-self dsDNA, leading to transcription into dsRNA. These non-self RNA polymerase III transcripts, such as Epstein–Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB activation through the RIG-I pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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