Thermo Fisher Scientific Phospho-PKM2 (Ser37) Polyclonal Antibody
PKM2 단백질의 Ser37 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal 항체입니다. Western blot과 IHC(Paraffin)에 적합하며, Human, Mouse, Rat 시료에 반응합니다. 고순도 정제, 1 mg/mL 농도의 액상 형태로 제공되며 연구용으로 사용됩니다.
- 카탈로그번호
- PA5105500
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-PKM2 (Ser37) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PKM (Accession P14618), corresponding to amino acid residues around phosphorylated Ser37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816928 |
Product Specific Information
This antibody detects endogenous levels of PKM2 only when phosphorylated at Ser37.
Target Information
PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. PKM2 interacts with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. It also binds Opa protein, a bacterial outer membrane protein involved in gonococcal adherence and invasion of human cells, suggesting a role in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms of PKM2 have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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