Thermo Fisher Scientific PDI Monoclonal Antibody (RL90), Alexa Fluor 647
Alexa Fluor 647로 표지된 PDI 단클론 항체로, 인간, 생쥐, 햄스터, 돼지, 랫트 시료에서 단백질 디설파이드 이성질화효소(PDI)를 검출. 면역세포염색(ICC/IF)에 적합하며, 고순도 Protein A 정제 및 안정적 형광 신호 제공.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RL90 |
| Immunogen | Purified rat PDI protein |
| Conjugate | Alexa Fluor™ 647 |
| Excitation / Emission Max | 650 / 671 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2662488 |
Additional Formats
- Unconjugated: MA3-019
- Alexa Fluor 488: MA3-019-A488
- Alexa Fluor 555: MA3-019-A555
- Custom conjugation available upon request
Product Specific Information
MA3019A647 detects protein disulfide-isomerase (PDI) from human, rat, porcine, and mouse tissues as well as hamster cells.
The MA3019A647 antigen is purified rat PDI.
Target Information
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds.
At the cell surface, it acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially modifying exofacial proteins.
Inside the cell, PDI assists in forming or rearranging disulfide bonds of nascent proteins.
At high concentrations, it functions as a chaperone preventing aggregation of misfolded proteins; at low concentrations, it may promote aggregation.
PDI also participates in structural modification of the TG precursor during hormone biogenesis and serves as a structural subunit of enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
It acts as a receptor for LGALS9, retaining P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity, altering plasma membrane redox state, and enhancing cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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