Thermo Fisher Scientific SOCS1 Recombinant Rabbit Monoclonal Antibody (5T6Z10)
SOCS1 단백질을 인식하는 재조합 토끼 단클론 항체로, IHC, ICC/IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. HEK293 세포에서 발현된 IgG 형식의 액상 항체로, -20°C 보관. 친화 크로마토그래피로 정제됨.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5T6Z10 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human SOCS1 (NP_003736.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094184 |
Product Specific Information
Immunogen sequence:
MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT
Target Information
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate immune cell responses to cytokines. SOCS1 suppresses dendritic cell and T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, which is essential for type I and II cytokine receptor signaling. SOCS1 also has E3 ubiquitin protein ligase activity, leading to polyubiquitination and proteasomal degradation of target proteins. Through this mechanism, SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating degradation of the adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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