Thermo Fisher Scientific GDF15 Recombinant Rabbit Monoclonal Antibody (10K4Y8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10K4Y8

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GDF15 (NP_004855.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GDF15,uniProtId:Q99988-1,ncbiNodeId:9606,antigenRange:100-200,antigenLength:308,antigenImageFileName:MA5-51358_GDF15_Q99988-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51358_GDF15_Q99988-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3093072

Product Specific Information

Immunogen sequence: HLHLRISRAA LPEGLPEASR LHRALFRLSP TASRSWDVTR PLRRQLSLAR PQAPALHLRL SPPPSQSDQL LAESSSARPQ LELHLRPQAA RGRRRARARN G

Target Information

GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15`s involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.