Thermo Fisher Scientific MRCK beta Polyclonal Antibody
MRCK beta 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 IHC에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도(>95%) 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: - References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1630–1680 of human MRCK beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553457 |
Product Specific Information
- Detects endogenous MRCK beta protein at a molecular weight of 194 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
CDC42BPB is a serine/threonine kinase involved in actin cytoskeleton assembly and organization.
Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK-alpha, MRCK-beta) contain a cysteine-rich motif and a pleckstrin homology domain.
MRCKs phosphorylate nonmuscle myosin light chain, influencing actin-myosin contractility.
MRCK-alpha can phosphorylate and activate LIM kinases downstream of Cdc42, leading to ADF/Cofilin inactivation and actin cytoskeletal reorganization.
Additionally, MRCK-alpha influences neurite outgrowth promoted by Cdc42 and Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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