Thermo Fisher Scientific Phospho-PKD1/2/3/PKC mu (Ser738, Ser742) Polyclonal Antibody
PKD1/2/3/PKC mu의 Ser738 및 Ser742 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC에 적합하며 Human, Mouse, Rat에 반응. 액상 형태로 -20°C 보관.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKD1 (Accession Q15139), corresponding to amino acid residues around phosphorylated Ser738. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816469 |
Product Specific Information
This antibody detects endogenous levels of PKD1/2/3/PKC mu only when phosphorylated at Serine 738 and Serine 742.
Target Information
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC. It regulates MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, and cell survival through NF-kappa-B activation. Also involved in cell migration, differentiation (via HDAC7 nuclear export), proliferation (via MAPK1/3 signaling), and plays roles in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis, and inflammatory responses. Phosphorylates EGFR on dual threonine residues, suppressing EGF-induced MAPK8/JNK1 activation and JUN phosphorylation. Phosphorylates RIN1, enhancing its binding to 14-3-3 proteins and modulating Ras signaling. Functions downstream of G-protein beta/gamma subunits to maintain Golgi structure and protein transport along the secretory pathway, particularly in trans-Golgi network vesicle fission.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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