Thermo Fisher Scientific PHIP Polyclonal Antibody
Human PHIP 단백질(pleckstrin homology domain interacting protein)에 특이적인 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1600 and 1650 of human pleckstrin homology domain interacting protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse
Target Information
PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein containing eight N-terminal WD40 repeats and two bromodomains.
It is expressed in skeletal muscle (cytosol and nucleus) and primary beta cells (nucleus) and acts as a transcriptional activator.
PHIP interacts with insulin receptor substrate (IRS) family proteins, which mediate insulin receptor signaling and are critical for beta cell proliferation and survival.
PHIP associates with the PH domain of IRS-1, potentially linking IRS-1 to insulin receptors, playing a vital role in insulin signaling regulation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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