Thermo Fisher Scientific PHIP Polyclonal Antibody
PHIP 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. 인간 PHIP 단백질의 1600–1650 영역을 면역원으로 사용. 4°C에서 보관하며, 수령 후 1년의 안정성 보장. 마우스 단백질과 교차 반응 예측.
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1600 and 1650 of human pleckstrin homology domain interacting protein (PHIP). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- 권장 유효기간: 수령일로부터 1년
- 100% 서열 동일성 기반으로 Mouse 단백질과 반응이 예측됨
Target Information
PHIP (pleckstrin homology domain interacting protein), also known as NDRP or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator.
PHIP interacts with members of the insulin receptor substrate (IRS) family, which mediate insulin receptor signaling and play an important role in insulin-producing beta cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role in insulin signaling regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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