Thermo Fisher Scientific BCR Polyclonal Antibody
BCR 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, Flow cytometry, IP 등 다양한 응용에 사용 가능. 인간 BCR 단백질의 1221-1271 잔기 영역을 면역원으로 제작. 1 mg/mL 액상 형태로 제공되며 4°C 보관. 연구용 전용.
- 카탈로그번호
- A302057Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific BCR Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 0.5 µg / 1×10⁶ cells in 150 µL |
| Immunoprecipitation (IP) | 10 µg / mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1221 and 1271 of human breakpoint cluster region (BCR) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, commonly found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene.
The translocation produces a fusion protein encoded by sequences from both BCR and ABL (chromosome 9 breakpoint).
Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear. The protein exhibits serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac.
Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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