Thermo Fisher Scientific Phospho-Caveolin 2 (Tyr19) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-060 detects phospho-caveolin-2 Y19 from human and mouse samples.
It has been successfully used in Western blot and immunofluorescence procedures.
By Western blot, this antibody detects an approximately 21 kDa protein representing phospho-caveolin-2 Y19 from COS-7 cells transiently transfected with the mouse caveolin-2 gene.
Immunofluorescent staining of phospho-caveolin-2 Y19 in NIH 3T3 cells using PA1-060 results in a distinct punctate staining pattern at the cell periphery.

The PA1-060 immunogen is a synthetic phosphopeptide corresponding to residues M(14) A D D A (pY) S H H S G C(25) of mouse CAV2.
This peptide (Cat. # PEP-180) is available for use in neutralization and control experiments.

Target Information

Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of various lipid and protein molecules.
These organelles play pivotal roles in lipid metabolism, growth regulation, signal transduction, and apoptosis.
Caveolin interacts with and regulates heterotrimeric G-proteins.
There are three known members of the caveolin multigene family encoding 21–24 kDa integral membrane proteins that form the major structural component of the caveolar membrane in vivo.
Caveolin-2 is abundantly expressed in fibroblasts, differentiated adipocytes, smooth and skeletal muscle, and endothelial cells.
Caveolin-1 expression is similar to caveolin-2, while caveolin-3 expression is limited to muscle tissue types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.