Thermo Fisher Scientific Adiponectin Receptor 1 Polyclonal Antibody
Thermo Fisher Scientific의 Adiponectin Receptor 1 폴리클로날 항체는 인간 및 랫에서 반응하며 Western blot에 최적화되어 있습니다. 합성 펩타이드 면역원 기반으로 제조되었으며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues R(20) E A D T V E L A E L G P L L E E K(37) of human Adiponectin Receptor 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2221905 |
Product Specific Information
PA1-059 detects human and rat adiponectin receptor 1.
It has been successfully used in Western blot procedures and detects an ~42 kDa protein corresponding to human adiponectin receptor 1 from transfected hepatocytes.
The immunogen is a synthetic peptide corresponding to residues R(20) E A D T V E L A E L G P L L E E K(37) of human Adiponectin Receptor 1.
Target Information
Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine.
Blood adiponectin levels are decreased under conditions of obesity, insulin resistance, and type 2 diabetes. Administration of adiponectin induces glucose-lowering effects and ameliorates insulin resistance in mice.
Adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect is mediated by increased fatty-acid oxidation through activation of AMP kinase and PPAR pathways.
Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) are abundantly expressed in skeletal muscle and liver, respectively. These receptors contain seven transmembrane domains but are distinct from G-protein-coupled receptors. Expression or suppression of AdipoR1/R2 confirms their role in mediating adiponectin-induced AMP kinase and PPAR activation, fatty-acid oxidation, and glucose uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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