Thermo Fisher Scientific Mouse IL-10 Recombinant Protein, eBioscience

Applications

• Assay-dependent
• Control (Ctrl): Assay-dependent

Publications

• Miscellaneous PubMed (Misc): 1 publication available

Product Specifications

Product Specific Information

Interleukin-10 (IL-10), also known as Cytokine Synthesis Inhibitory Factor (CSIF), is an 18.6 kDa protein composed of 160 amino acids and shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI.
IL-10 exhibits multiple biological activities, including:

• Inhibition of macrophage-mediated cytokine synthesis
• Suppression of delayed-type hypersensitivity response
• Stimulation of Th2 cell response leading to elevated antibody production

Mouse IL-10 is produced by various cell types, including activated Th2 cells, fetal thymocytes, monocytes/macrophages, keratinocytes, B cells, and glial cells.

Purity: >98%
Molecular Weight: 18.7 kDa

Target Information

IL-10 encodes a cytokine primarily produced by monocytes, with some production by lymphocytes. It plays key roles in immunoregulation and inflammation through:

• Down-regulation of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages
• Enhancement of B cell survival, proliferation, and antibody production
• Inhibition of NF-kappa B activity
• Regulation of the JAK-STAT signaling pathway

Knockout studies in mice indicate IL-10 is essential for intestinal immune regulation.
Mutations in IL10 are associated with increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Diseases linked to IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.