Thermo Fisher Scientific Phospho-RyR2 (Ser2808) Polyclonal Antibody
Phospho-RyR2 (Ser2808) 항체로 인간, 생쥐, 랫트 시료에서 RyR2 단백질의 인산화 상태를 검출. Western blot 및 IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 4°C 또는 -20°C에서 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human RyR2 around the phosphorylation site of Serine 2808 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553708 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of approximately 565 kDa.
Purity is >95% as determined by SDS-PAGE.
Target Information
Dihydropyridine receptor (DHPR) is a surface membrane protein essential for excitation-contraction coupling in striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) form key intracellular junctions where surface membrane depolarization triggers Ca²⁺ release from internal stores. The DHPR alpha1-subunit contains a cytoplasmic loop involved in RyR interaction, and its phosphorylation is thought to influence DHPR-RyR functional coupling. Mutations in DHPR alpha1 can cause excitation-contraction uncoupling, leading to muscular dysgenesis and reduced Ca²⁺ current density in RyR-deficient cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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