Thermo Fisher Scientific Phospho-PKC Pan (Thr497) Polyclonal Antibody
PKC 계열 단백질의 인산화 상태(Thr497)를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에서 사용 가능하며, Human, Mouse, Rat 반응성. 고순도(>95%) 항체로 세포 신호전달 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human PKC-pan around the phosphorylation site of Threonine 497 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553707 |
Product Specific Information
This antibody detects endogenous levels of PKC alpha, beta-I, beta-II, gamma, delta, epsilon, eta, zeta, and theta isoforms only when phosphorylated at a residue homologous to threonine 497 of human PKC alpha.
Purity is >95% by SDS-PAGE.
Target Information
Members of the protein kinase C (PKC) family play a key regulatory role in various cellular functions including cell growth and differentiation, gene expression, hormone secretion, and membrane function.
PKCs were originally identified as serine/threonine protein kinases dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor-promoting phorbol esters bind to and activate PKC.
PKCs can be subdivided into at least two major classes:
- Conventional (cPKC) isoforms: α, βI, βII, γ
- Novel (nPKC) isoforms: δ, ε, ζ, η, θ
Expression patterns differ among tissues, and PKC family members exhibit distinct cofactor dependencies. For example, the kinase activities of nPKC δ and ε are independent of Ca²⁺.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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