Thermo Fisher Scientific CD123 Monoclonal Antibody (5B11), APC, eBioscience
Thermo Fisher Scientific의 CD123 Monoclonal Antibody (5B11), APC은 마우스 CD123을 인식하는 Rat IgG2a 항체로, Flow Cytometry에 최적화되어 있습니다. APC 형광 표지로 651/660 nm의 Excitation/Emission 특성을 가지며, 4°C 암저장 조건에서 안정적입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD123 Monoclonal Antibody (5B11), APC, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.5 µg/test
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B11 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_891361 |
Additional Formats:
Product Specific Information
The 5B11 monoclonal antibody reacts with mouse CD123, the alpha chain of the IL-3 receptor. This 60–70 kDa transmembrane protein binds IL-3 with low affinity by itself, and with high affinity when associated with CD131 (common beta chain) or AIC2A (IL-3beta). CD123 requires the beta chain for intracellular signal transduction.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested by flow cytometric analysis of mouse bone marrow cells.
Use ≤0.5 µg per test (100 µL final volume). Optimal titration recommended.
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family. It forms a heterodimer with the common beta (CDw131) subunit. IL-3Ra transmits IL-3 signals and its overexpression has been observed in acute myeloid leukemia (AML) blasts compared to normal hematopoietic cells, making it a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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